Dr. Noam Sobel: How Smells Influence Our Hormones, Health & Behavior | Huberman Lab Podcast

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Published 2023-05-01
In this episode, my guest is Noam Sobel, PhD, professor of neurobiology in the department of brain sciences at the Weizmann Institute of Science. Dr. Sobel explains his lab’s research on the biological mechanisms of smell (“olfaction”) and how sensing odorants and chemicals in our environment impacts human behavior, cognition, social connections, and hormones. He explains how smell is a crucial component of “social sensing” and how we use olfaction when meeting new people to determine things about their physiology and psychology, and he explains how this impacts friendships and romantic partners. He explains how smell influences emotions, hormone levels, memories and the relationship between breathing and autonomic homeostasis. He describes how smell-based screening tests can aid disease diagnosis and explains his lab’s work on digitization of smell — which may soon allow online communication to include “sending of odors” via the internet. Dr. Sobel’s work illustrates how sensitive human olfaction is and how it drives much of our biology and behavior.

#HubermanLab #Science #Smell

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Dr. Noam Sobel
Lab website: www.weizmann.ac.il/brain-sciences/worg
Lab Facebook: www.facebook.com/odorspaceWORG
Publications: www.weizmann.ac.il/brain-sciences/worg/publication…
Twitter: twitter.com/LabWorg

Articles
The Age of Olfactory Bulb Neurons in Humans: bit.ly/41NMjb6
The Privileged Brain Representation of First Olfactory Associations: bit.ly/3LGEePP
Mechanisms of scent-tracking in humans: go.nature.com/41Sm03w
Measuring and Characterizing the Human Nasal Cycle: bit.ly/44dqGmi
Human non-olfactory cognition phase-locked with inhalation: go.nature.com/44iPIQQ
A social chemosignaling function for human handshaking: bit.ly/3Lo5kK6
There is chemistry in social chemistry: bit.ly/41TVIhq
MHC-dependent mate preferences in humans: bit.ly/41SbgCc
An Exteroceptive Block to Pregnancy in the Mouse: go.nature.com/3VnxRnN
Fear-Related Chemosignals Modulate Recognition of Fear in Ambiguous Facial Expressions: bit.ly/3NqAPpD
Sniffing the human body volatile hexadecanal blocks aggression in men but triggers aggression in women: bit.ly/3oQ6NBv
Menstrual Synchrony and Suppression: go.nature.com/3LRF9xf
Regulation of ovulation by human pheromones: go.nature.com/44jODbt
Human Tears Contain a Chemosignal: bit.ly/41Qmkjr
Why Only Humans Shed Emotional Tears: bit.ly/41W71pl
Revisiting the revisit: added evidence for a social chemosignal in human emotional tears: bit.ly/44dygNJ
Increase of tear volume in dogs after reunion with owners is mediated by oxytocin: bit.ly/41W73gX
An olfactory self-test effectively screens for COVID-19: go.nature.com/3Vj6z1S

Other Resources
Joachim Löw video:    • Germany’s Coach Smells Fingers After ...  
Osmo: osmo.ai/
Odor Space: odorspace.weizmann.ac.il/

Timestamps
00:00:00 Dr. Noam Sobel
00:03:46 Sponsors: ROKA, Thesis, Helix Sleep
00:06:46 Olfaction Circuits (Smell)
00:14:49 Loss & Regeneration of Smell, Illness
00:21:39 Brain Processing of Smell
00:24:40 Smell & Memories
00:27:52 Sponsor: AG1 (Athletic Greens)
00:29:07 Humans & Odor Tracking
00:39:25 The Alternating Nasal Cycle & Autonomic Nervous System
00:48:18 Cognitive Processing & Breathing
00:54:47 Neurodegenerative Diseases & Olfaction
01:00:12 Congenital Anosmia
01:05:01 Sponsor: InsideTracker
01:06:19 Handshaking, Sharing Chemicals & Social Sensing
01:15:07 Smelling Ourselves & Smelling Others
01:22:02 Odors & Romantic Attraction
01:24:58 Vomeronasal Organ, “Bruce Effect” & Miscarriage
01:40:20 Social Chemo-Signals, Fear
01:50:26 Chemo-Signaling, Aggression & Offspring
02:03:57 Menstrual Cycle Synchronization
02:12:11 Sweat, Tears, Emotions & Testosterone
02:27:46 Science Politics
02:37:54 Food Odors & Nutritional Value
02:45:34 Human Perception & Odorant Similarity
02:52:12 Digitizing Smell, COVID-19 & Smell
03:05:50 Medical Diagnostic Future & Olfaction Digitization
03:10:55 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac - www.blabacphoto.com/

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All Comments (21)
  • As a blind guy I thoroughly enjoyed this discussion and sincerely hope you have this doctor back for another 3 hours or more sometime in the future!! Thank you for bringing this great content to the masses who otherwise wouldn’t get to enjoy learning such great information!!
  • @twintelemusic
    Andrew, can you please have a podcast dedicated solely to those who are struggling with their smell after having covid? it has been almost two years and my smell is still distorted. I've tried everything from carnivore diet, extended fasting, psilocybin, supplements, smell training, but no cure. Any improvement i've had has been microscopic. My identical twin sister had covid the exact same time as me but her smell came back within a few months. I dont know why more people arent talking about this.
  • @darby3762
    Intro less than 10 seconds, cuts right to the chase, mellow voice, neutral background and outfit, no crazy background music = an oasis to my overstimulated senses in today's content deluge. Thank you!
  • The relationship between nasal airflow and ADHD was astonishing. It makes a strong case for meditation and breath work. I personally love the Win Hof Method.
  • @adamfranklin0
    The quality of your guests and your content is unmatched. Thank you for the amazing gift of wisdom and knowledge that you pass to us every episode. Always motivating and inspiring.
  • I have always had an acute sense of smell. Some of my first memorys are sitting in church very young and being overwhelmed by people's perfume. To point I would feel sick. My smell at nearly 50 is still exceptional. I can often smell things others can't. I often feel I can taste some smells.
  • At around the 40min mark, Noem briefly mentions that nostril air flow can tell if someone has adhd, and if they are medicated or not. This brief mention has me fascinated, I’d love to learn more about it. I have adhd, I was diagnosed in Jan after 52yrs of struggling thru life with no idea why. The road to diagnosis was long and expensive ( yet so worth it, life has improved immensely ) Imagine if a nostril/breath test was developed as a diagnostic tool. That could help cut costs for diagnosis. Many people simply can’t afford to see a psychiatrist, so they spend their life suffering when a solution is possible, I find that so sad. Psychiatrists would lose $$ and clients, yet their loss wouldn’t come close to the adhd ‘tax’ neurodivergent people pay.
  • @MrWylis
    There's never a bad Huberman Lab podcast... But this one an absolute beauty.
  • Dr. Huberman. You are a godsend. I’ve sent your video on grieving to a few people this month and they both thanked me for your wisdom. You are an incredible human being, a Dale Carnegie of our generation
  • @debrabrunett6336
    As a former hospice aide , I noticed that diseases have distinct odors, my olfactory sense was honed and since that experience began I know notice people by the smells. This the my primary sense. I can smell disease. This discussion was enlightening and I have a much clearer understanding of my sense of smell 🌺 You both were a pleasure to listen to
  • @schumannbeing
    I've always thought it's unfortunate that besides foods and fragrances we don't really have a set-based form of entertainment the way we have music for the ear and visual arts for the eyes. I've noticed that my nose has a very strong connection with my brain and my memory because certain smells can immediately trigger a strong sense of nostalgia or recollection of a long forgotten memory much more efficiently than a visual or audible trigger might. We need more scentertainment!
  • @CalixtoErico
    Dr. Sobel is a delightful guest. I hope he returns sooner rather than later with more terrific things to teach and share.
  • I had contacted covid back in 2020 and I have lost my sense of smell and it really sucks. I had no idea how much smell really does affect us. Definitely helps us with smelling danger. One time I was cooking I stepped away for a moment and I didn't realize that I was burning our food until I saw smoke. I had no sense of smell. It really sucks. I'm going on 3 years. My sense of smell is there but very very faintly it's not as prominent as it used to be. When I smell new things I get so excited. So now I know how my dog feels LOL when she's out on her walks
  • Huge gratitude to Dr. Sobel. Amazed me most his statement in the future we'll have a tool for smelling disease.
  • @ryan16202
    This guest is a nerd in the very best sense of the word. Appreciate his knowledge.
  • @SupraSav
    The content on this channel is unmatched on YT. Thanks for another phenomenal video. The only channel I will watch for more than 30 mins on YT.
  • Hi! I´m from Argentina and I´m currently doing my bachelor's degree in Neuroscience at American University in Washington dc. As a student and a big fan of neuroscience and neurobiology, I´m amazed by the way you address each topic. I would really like to watch an episode about hormones and the brain of women, and the effects that being in a different stage of their monthly cycle could have.
  • Human hair is an amazing medium for odour recording and transfer. This topic just hasn't been in focus enough. I have long hair and when wearing it loose and smell it at the end of the day feels like rewind and replay of all the places I visited, people I've met and foods I ate. It's so much fun.
  • I just want to appreciate that in the first 3 minutes of the introduction, you summarize what people will learn in the episode. The way it is done with real-life examples that everyone can relate to is great. It invites viewers to ask a lot of questions and generates curiosity, which is great for retention. Also, time stamps are helpful for scoping the topic and understanding the big picture. Pairing all of this with Dr. Huberman's amazing ability to synthesize and process complicated information into something digestible for anyone, coupled with his ability to ask great questions during guest episodes, and the fact that the studio and visual aspects of the recording are also helping me focus, makes for a very optimized and well-thought-out learning environment. There are probably many more subtle aspects to this, but these ones stood out the most to me and I was able to catch them with my current understanding of learning efficiency.
  • @sonja7335
    My assumption that I as an individual perceive odours and smells different to other people was refuted. Being humbled by science is the best way to learn and grow. Thank you both for this highly interesting episode, I didn't want it to stop.