The Science of Healthy Hair, Hair Loss and How to Regrow Hair | Huberman Lab Podcast

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Published 2023-04-10
In this episode, I explain the biology of hair, hair growth, why hair growth slows and what causes hair to stop growing and/or “fall out.” I discuss the essential role of hair stem cells and other supporting biological factors for healthy hair growth. Then I describe various approaches (mechanical and chemical) to slow hair loss by increasing blood flow to hair stem cells, including minoxidil, tadalafil, PRP, microneedling, Botox and ketoconazole treatments. I also discuss how age-related hormone changes cause hair loss and explain the effectiveness of treatments such as caffeine, saw palmetto, growth hormone, finasteride and dutasteride. For all hair growth options, I describe potential side effects, how soon to expect results and the amount of hair regrowth to expect and I highlight effective combination treatments for hair regrowth even in hair “dead” (bald) zones. For many listeners, thinning, brittle hair, or pattern baldness are a source of anxiety and stress. This episode explains the mechanisms underlying hair regrowth tools and the science behind them so that you can evaluate potential treatments and associated side-effect profiles and select the best one(s) for you.

#HubermanLab #Science #HairGrowth

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Articles
Microneedling and Its Use in Hair Loss Disorders: A Systematic Review: link.springer.com/article/10.1007/s13555-021-00653…
Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review: www.karger.com/Article/Fulltext/508228
The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta-analysis: onlinelibrary.wiley.com/doi/10.1111/dth.13741
Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles in vitro: academic.oup.com/bjd/article-abstract/171/5/1031/6…
The structure of people’s hair: peerj.com/articles/619/

Note: The Huberman Lab podcast has no affiliation with or financial benefit from any of the products listed below, which are provided as a useful reference only.

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Intelligent: intelligent.shop/products/intelligent-shampoo

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R+Co: www.randco.com/collections/dallas-collection/produ…

Microneedling www.amazon.com/s?k=microneedling+hair+2mm&crid=OOD…

Timestamps
00:00:00 Hair
00:04:13 Sponsors: Helix Sleep, HVMN, ROKA
00:08:04 Psychological States & Hair
00:13:19 Hair Anatomy & Stem Cells
00:26:05 3 Phases of Hair Growth
00:35:40 Sponsor: AG1 (Athletic Greens)
00:36:55 Minoxidil & Blood Flow
00:45:37 Increase Blood Flow: Massage, Tadalafil, Platelet-Rich Plasma (PRP), Microneedling
00:56:10 Microneedling, Minoxidil & “Dead Zones”
01:00:13 Sponsor: LMNT
01:01:25 Botox Treatments
01:06:27 Androgens, Hair Growth & Pattern Hair Loss; Scalp vs. Beard Hair
01:15:46 Topical Caffeine & Slowing Hair Loss
01:21:06 IGF-1: Growth Hormone & Sermorelin; Insulin Sensitivity: Myo-Inositol
01:25:52 Iron & Hair Growth
01:27:04 5-Alpha Reductase & Saw Palmetto; Curcumin
01:33:22 Ketoconazole & Offsetting Hair Loss
01:38:46 Topical & Oral Finasteride
01:51:00 Post- Finasteride Syndrome
01:56:01 Dutasteride
01:58:53 Mechanical & Chemical Stimulation for Hair Growth
02:02:46 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac - www.blabacphoto.com/

Disclaimer: hubermanlab.com/disclaimer

All Comments (21)
  • @tomdevine7395
    Great overview Andrew. I have tried about 90% of treatments you reviewed so if anyone is interested I can give some thoughts. First, I am a male and started losing hair (receding hairline) around the age 20 (1985). My doctor gave me good advice. He said, “take a multivitamin, exercise, eat healthy, cut it short, don’t stress and enjoy your life”. In retrospect, he was 100% correct. I started Rogaine in the early 90’s not long after it came out. I did notice a slowing of loss although I didn’t like the greasy feeling of the solution (2x per day). When Propecia came out around 1998 I started it immediately and, in combination with Rogaine, saw about a 95% reduction in hair loss. BTW, I was also eating right, exercising, taking vitamins, etc. But, I did have very high stress jobs so that had an effect. Fast forward to 2015. My hair was maintaining (although 85% grey by then) and I didn’t see the side-effects that people touted. No libido change although we had three little kids so that’s enough energy spend to drain libido anyways…but I digress. I got quite ill in 2015 while traveling to China. After that I noticed an increase in hair loss with significant loss of leg and arm hair. My doctor (a different one) told me it was from aging. I didn’t think it was. In 2018 I was diagnosed with scarring alopecia and have been fighting that. Up until 2016 I would actually see small angel hairs on my forehead telling me that the Rogaine/Propecia combo was working. Then it all became hairless, smooth, and shiny. My scalp often hurt as if it was burning and I would feel the same on my arms, legs, and back. I am convinced that this all stemmed from an illness I caught in Asia or from getting my first flu shot in 2015 (I don’t react well to vaccines). Here’s what I know works. Propecia works very well and would be my #1 recommendation as long as you aren’t prone to the side-effects. Rogaine also works well but frankly it’s tiring to apply it twice per day and then have the greasy feeling in your hair during work and on your pillow. It’s inconvenient but works. There are a million shampoos/conditioners touting miracles which I would ignore. The ones I use are Nizoral (2x/week) and Klorane Shampoo with Quinine. For some reason the Quinine in Klorane really helped my scalp inflammation and the burning sensation. I also use Klorane’s conditioner. In both cases, you need to leave the shampoos on for about 5 minutes to maximize benefits. I have also used the shampoo/conditioner from Regenepure and had good results but found the Klorane was better. I use a hair shampoo massager brush and “press” it into my scalp 60 times, twice daily for blood circulation and have found that to be effective as well. You can get those on Amazon. I’m 57 and still have a lot of hair but it’s been a hard fight. In some ways, I think I should have followed my doctors advice from 1985. I would have fretted a lot less if I had just “taken my hair worries out of the equation” and lived my life. But, in the mid-90’s I told my wife, “by 2010 they will have cured balding and we’ll all have hair, I just need to save as much of mine as I can”. Then again I thought cold fusion would be commonplace by 2020 so I’m 0 for 2. And last, I also considered hair transplants but I can’t because of my scarring alopecia diagnosis, the success rate is near zero. Even then, one person once said, “hair transplantation is like parachuting fresh troops into a field where everyone on the ground is dead or dying”. Whatever hair you have there will still get its DNA queue and die off so then you’re stuck with only the transplanted hair. Eventually you run out of donor hair to move. We need hair to be grown in the lab that can be transplanted. For the 2 people who might have stayed this long to read this comment, thank you and I wish you the best in your quest to keep your hair.
  • @shark3380
    If this revives my hairline i ll donate everything
  • @stevekannan6076
    One of the best and most informative videos I have seen. Balding is such a curse, but if you fight this battle, you can actually win. I started to lose my hair when I was 19. I went on FIN and MIN almost immediately but unfortunately I kept losing ground due to my aggressive hairloss (Heading to norwood 7 like the rest of my family). Once I started microneedling my shedding has stopped after about two months and by month 4 my hair became way thicker + lots of Vellus hairs which became terminal by month 6. Do not give up guys, there's no officially cure but if it worked for me it should work on 99% of the people. just make SURE to pick high quality Pen with high quality needles otherwise you will do more harm than good (Do NOT use Rollers).
  • @kripadeep
    The time I faced hair fall, I did all the following to successfully reduce it - .. Make a habit of doing hot oil scalp massages into your routine. .. Do not use very hot water when rinsing your hair. .. Shield your hair from too much sweat. .. Use a wide-toothed neem comb to brush out wet hair. .. Reduce your sugar and unhealthy food consumption. .. Use mild anti hair fall shampoo and hair oil like littleeextra coccconion. .. Maintain a positive mindset for general well being.
  • @skycaptain141
    As someone who started losing his hair in his teens, the psychological effects are something I am still dealing with in my late 20s.
  • @HarpaAI
    🎯 Key Takeaways for quick navigation: 00:00 🎙️ Introduction to hair science importance. 01:26 🧪 Hair stem cell niche diversity. 02:51 💆‍♀️ Slowing, halting, reversing hair loss. 03:46 💡 Debunking inherited balding myth. 08:04 🧠 Psychological impact of hair loss. 10:00 📊 Prevalence of significant hair loss. 13:39 🧬 Hair growth process. 16:00 💧 Sebaceous glands and hair health. 20:12 🕶️ Factors affecting hair health. 20:41 💧 Sebum's roles, immune function. 22:35 🩺 Blood flow's role in hair growth. 24:30 💆‍♂️ Techniques for enhancing growth. 27:13 📈 Hair growth phases. 34:15 ⏳ Hormones and hair growth phases. 37:38 💉 Minoxidil and its effects. 41:25 🧪 Minoxidil side effects. 44:13 🩺 Minoxidil mechanism and dosing. 47:39 🩸 Blood flow treatments. 51:02 🔬 PRP treatment. 52:28 📏 Micro-needling. 55:22 🌱 Growth through microdamage. 56:19 🤝 Combining treatments. 57:44 💉 Long-term Minoxidil use. 01:00:01 💧 Electrolytes (LMNT). 01:01:26 💉 Botox for hair loss. 01:02:22 🧪 Botulinum neurotoxin. 01:03:47 🩺 Botox scalp application. 01:05:38 🚶‍♀️ Cutis verticis gyrata. 01:08:01 ⚙️ IGF-1 and cyclic AMP. 01:09:00 🦠 Androgen-related alopecia. 01:11:53 💈 DHT and hair loss. 01:16:08 ☕ Caffeine and hair preservation. 01:21:23 💤 Increasing IGF-1 via sleep. 01:23:19 🩺 Natural IGF-1 production. 01:24:42 💊 Supplements for insulin sensitivity. 01:28:35 🍃 Saw palmetto. 01:33:19 🧼 Ketoconazole shampoo. 01:39:24 🏃‍♂️ Finasteride. 01:42:19 🩺 Finasteride application. 01:43:12 📊 Logarithmic DHT reduction. 01:44:06 🚧 Gradual DHT reduction. 01:45:00 🧪 Starting dosages for finasteride. 01:47:25 📆 Long-term finasteride use. 01:51:07 🚨 Post-finasteride syndrome. 01:56:44 💊 Dutasteride. 02:00:32 👥 Individual responses and combinations. 02:02:53 🎙️ Podcast engagement. 02:03:22 💊 Supplements and social media. 02:04:20
  • @VietYork
    00:03 Hair loss and ways to slow or reverse it 05:36 Hair loss is a significant concern for many individuals. 16:43 Hairs are made up of proteins called keratins and grow from stem cells in a little cave below the root. 21:26 The erector pili muscle contracts when we get cold or scared, causing the hairs to stand up. 31:18 There are three critical stages of the hair life cycle: antigen phase, catagen phase, and telogen phase. 36:20 Blood flow is crucial for hair growth 46:10 Increasing blood flow to the scalp can slow down or maintain hair loss. 51:10 PRP and microneedling are two treatments for hair regrowth that involve the use of needles. 1:00:58 Botox injections are being used to offset hair loss by decreasing squinting and increasing blood flow to the scalp. 1:05:59 Botox injections can reduce scalp squinting and hair loss 1:16:12 Topical caffeine application can be as effective as minoxidil application for offsetting hair loss. 1:20:55 Increase hair growth and maintain hair by stimulating the production of igf-1 and avoiding insulin resistance. 1:30:18 Saw palmetto and ketoconazole are commonly used compounds for hair growth. 1:35:12 Ketoconazole shampoo can help maintain hair and stimulate growth. 1:44:55 Topical finasteride is associated with fewer side effects compared to oral finasteride. 1:49:34 Finasteride dosing recommendations 1:59:16 Combination of microneedling and finasteride is the most effective way to regrow hair 2:03:49 Huberman Lab offers free newsletters and toolkits on various topics. Crafted by Viet York from Molly․com
  • I'm a board-certified Dermatologist and received this video recently from a friend for an opinion. This is such a SUPERB lecture. Deep knowledge about health should be available for the general public as much as possible so people are able to get detailed information to think about that, be curious about themselves, be aware of they own clinical trajectories and needs and also be agents of their own health. Even though some data about some emerging (and unexpected!) therapeutic options remain unclear, as he said, any discussion would be much easier for both, doctors and patients if both were capable of making decisions based on current science. Also I'd like to say that human body is so fascinating; if we learn more about our nature, and pay attention to what happens inside and outside of us, our body will perform beautifully for us. If your body is not performing beautifully enough, proper knowledge would always be useful for making decisions along with your doctor, especially when it comes to taking supplements or therapeutical drugs. In summary, I think that this video is very informative and highly recommended.
  • @AuraValemont
    For a woman who started losing her hair in her early 20s, this video is super important. Thank you Dr.
  • @drgarylinkov
    Definitely no magic with hair restoration. Excellent review Andrew. Medical therapy is critical for most patients considering hair transplant surgery.
  • @janicegriff71
    I can't believe no one is talking about this, but most hair loss if you're not pre-disposed with alopecia, can be solved with SUNLIGHT. Yes, sunlight. Only 15-30 minutes a day. Sunlight provides Vitamin D which is one key component for healthy hair. Our bodies also produces nitric oxide when we receive UV light from the sun, which relaxes the blood vessels and allows for improved bloodflow. Sounds a lot like minoxidil doesn't it? The only difference is that sunlight is FREE. The pharmaceutical company can't monetize the sun, that's why you don't be hear much about this remedy; and if you do a engine search, most articles talk about how the sun can "damage your hair" which is true if you spend hours in the sun when its hot, BUT your own body is smart enough to let you know that your head is getting hot. Obviously still wear sunscreen on your face and other areas, but with 15-30 minutes in the sun, usually won't be an issue. Hope this information can help people.
  • In the end, what i have extracted from the podcast is that Botox + Microneedling + massage + Caffeine + Optimal range of iron, is the best treatment with 0 side effects.
  • @kjdskgj
    Been struggling with hair loss lately so the timing of this couldn't have been greater. Thank you!
  • @rio20d
    Kevin from haircafe brought me here lol
  • I lost two thirds 0f my hair following a bout of severe illness (may well have been covid I didn’t test), I didn’t lose it months afterwards like most do, I lost it during — literally c;umps fell out over the period of a month (I’m v healthy and have never been so sick/weak in my entire life, it was like I had radiation poisoning!). That was 18m ago, I have managed to regrow my hair and it’s now growing back far thicker than before. Here’s what worked for me - raw liver every day, high dose ( 3 to 4gms) of flush niacin daily (I mix it with equimolar) l glutamine & 3000mcg of folic acid. I ate a ton more meat and eggs and took both marine and bovine collagen, I also started making raw milk kefir, drank bone broth. I used rosemary on my scalp - boiled up rosemary from the garden, sieved it and put it in a spray bottle and used it on my scalp daily. Cut back washing to once a week, and did a scalp treatment with rosemary essential oil every time. Stopped blowdrying my hair as much as possible (only if I was going somewhere I needed to look super groomed). And finally I said positive affirmations about my hair on my daily walk eg my hair is growing thick and strong, there are no impediments to my hairs growth, my hair is my crowning glory. It all worked together to regrow my hair to a condition where it’s now way better at 50 than it was at 30. Good luck to all of you suffering with hair loss, it’s v stressful particularly for women.
  • @fnu6565
    Honestly not sure why people are so happy about this video. All this guy did is pack everything we’ve heard about hair loss into one video and add his own twist. If you’ve been dealing with hair loss for any amount of time, you probably know about the various treatments out there and the potential side effects. The reason this continues to be a discussion is because hardly anybody is satisfied with those options. Either maintenance or potential side effects will lead you to stop or not even start. People are looking for a real solution, not another pontification. If he had an answer or really knew how to address this issue once and for all, then this video would be no more than a minute long. All this leaves you with is an array of options with uncertain roads, and putting you back to where you started, choosing none of them.
  • @mr0glass
    Only regret I have with taking fin is not starting earlier. Kept my hair for 20 years now thanks to it...but lost a few years of hair due to being scared of side effects that never happened anyway. Make sure you don't get propecia - you can get generic fin for prostates at 5mg and cut it in 5 pieces. Much much much cheaper.