How optimizing circadian rhythms can increase healthy years | Satchin Panda | TEDxBoston
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Published 2021-12-10
Professor Regulatory Biology Laboratory at Salk
Dr. Satchidananda Panda, a professor at the Salk Institute for Biological Studies in La Jolla, California. Satchin’s work deals specifically with the timing of food and it’s relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general.
Professor Panda explores the genes, molecules and cells that keep the whole body on the same circadian clock. A section of the hypothalamus called the suprachiasmatic nucleus (SCN) lies at the center of the body’s master clock and gets input directly from light sensors in the eyes, keeping the rest of the body on schedule. Panda discovered how these light sensors work, as well as how cellular timekeepers in other parts of the body function. He also uncovered a novel blue light sensor in the retina that measures ambient light level and sets the time to go to sleep and wake up every day.
In the process of exploring how the liver’s daily cycles work, Panda found that mice which eat within a set amount of time (12 hours) resulted in slimmer, healthier mice than those who ate the same number of calories in a larger window of time, showing that when one eats may be as important as what one eats. If the benefits of this “12-hour diet” hold true in humans, it could have profound impacts on treating overeating disorders, diabetes and obesity.
The circadian clock, he found, even mediates the immune system. Mice with a crucial circadian molecule missing had higher levels of inflammation in their bodies than other mice, suggesting that genes and molecules involved in the circadian clock could be drug targets for conditions linked to inflammation, such as infections or cancer. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
All Comments (21)
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I have had a bad sleeping pattern and circadian rhythms since I was a teenager and I can confirm whatever the doctor said. Though I'm only 33 years old, I have pre-diabetes, high blood pressure, overweight, anxiety, high cholesterol and triglycerides, and blood concentration. I never ever remember having a regular sleep pattern. My friends, save yourself before it's too late. Unfortunately, there aren't many resources about this and I'm so glad Doctor Satchin has invested in researching this topic. This is a really big deal but not talked about enough.
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I love the part where he mentions how his team discovered this, and my 94 years old grandma has been living exactly like that her entire life. Plus she is very strong and healthy at 94!! I guess we should all take this talk seriously. ☀️
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So interesting… in fact anywhere in the rural areas of the world , you’ll probably see healthier , happier people because they are so in tune with the movements of Nature . Living in fast-paced urban India , most of us have destroyed our cicadian rhythms ,right from when we were kids studying till late into the night till now when we’re binge-watching our favourite shows when we should be asleep.Modern life has taken a toll on our health , but we’re so entangled in it, that we can’t just throw everything to the wind to do what our grandparents knew how to do . All we can do is try .🙏🇮🇳
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So enlightening. Thank you so much.
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Absolutely brilliant! Thank you so much Dr Satchin Panda.
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Thank you for your wonderful and hopeful presentation!
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This is amazing! I doubt this is a more important TED Talk than this. Thank you Dr. Panda!!!
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Excellent information. Thank you.
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Great information. Thank you for sharing
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Great talk Satchin
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Thankyou Dr. Panda
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Enjoyed! Thank you great advise
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one of the best videos on youtube and by Ted Talks. Thank you Dr. Panda.
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Thanks Dr Panda for the amazing talk with good comparisons of our body to a car.Its so true about the circadian rhythm
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Simple. Sincere. Scientific. Super Dr Panda
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Thanks you so much 🙏
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Thank you doctor!
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The best video ever. I learnt soo much. I actually watch and discuss with my patients
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Excellent information!
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Great video, thanks
