Rat/Mouse Brain Hybrid Created: New CRISPR Method for Cross-Species Chimeras
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Published 2024-07-19
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Scientists grew a hybrid mouse with rat brain cells, using genetic modification and stem cells from a rat. Their new method for creating chimeras, based on CRISPR, could open the door to growing humanized organs in animals for transplantation into humans.
Note: Rat and mouse cortex is not wrinkly like human cortex. It is pretty smooth, as shown at 7:06.
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Link to paper (paywalled) www.cell.com/cell/abstract/S0092-8674(24)00308-8
Another video on chimeras: • Hybrid Monkey Breakthrough: A Step To...
Chapters:
0:00 Introduction
0:19 Blastocyst Complementation
1:39 New CRISPR Method
2:26 Forebrain Replacement
3:38 Staining the Brain
5:02 Interspecies Brain Hybrid
6:27 How Far?
7:05 Normal?
8:28 Persistent?
9:03 Synchronized Development
9:51 Cell-Autonomous Mechanisms
10:32 Human Organs in Animals
11:19 Limitations
11:37 Functional Connectivity
All Comments (21)
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1980: I bet there'll be flying cars in the future 2014: new rat just dropped
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damn that's crazy. instead of thinking about cheese it was probably thinking about cheese
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You have a knack for dumbing down information without insulting anyone. This was a great and exciting video.
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Me: "ya can we have affordable housing" The world: "best incan do is rat mouse chimera!"
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Cat girls are coming, guys
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My first tought was : "God if the Furies find this, we're in big trouble"
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This is mind blowing
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Even thought I don't fully understand most of your videos I can't avoid finding them really interesting. Keep up the great work!
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"So basically we genetically engineered a rat with body dysmorphia" '...why?' "it sounded cool"
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The pinky, the pinky and the brain brain brain brain..
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Another step closer to Humans being capable of photosynthesis.
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Is this a mat or a rouse?
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Ah yes, human horrors beyond our comprehension.
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Damn, Jurassic Park for real.
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I missed does this require immunocopromised?
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Interesting. I wonder what cause the conversation of the donor cells back to mouse cells. Chemical signals, environment, the body's immune system? So fascinating.
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2024: Cat girl jokes 2094: Genetically manufactured soldiers 2194: Completely genetically engineered social classes
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Wow that’s interesting. You make it easy to understand these things.
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Reminds me on a case here, germany. An old woman got an implant of calf tissue as transplanted organ. Because the choice was that or death and documentation was tight, since it was during WW2 She survived her son (saddly) and no doctor believes her I assume bodys can tolerate way more new cells than we know. Specially females, since their immune system is already optimised to survive pregnancy. And a lot becone mirco chimeras during that time.
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hey you got a big sponsor keep it up!
