A Winding Life Through Science: Virginia Man-Yee Lee

Science Communication Lab
Science Communication Lab
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2022-11-08に共有
www.iBiology.org/

When Virginia Man-Yee Lee., Ph.D., was growing up in Hong Kong in the 1950s and 1960s, her parents had certain expectations for their daughter that did not include a career in academics and especially science. But Lee felt an inescapable pull to science. Challenging stereotypes at the time of what a Chinese woman could accomplish, she became a leading researcher of Alzheimer’s and other neurodegenerative diseases. In this film, Lee recounts her inspiring journey made possible by her determination, positive outlook, resilience, and hard work.

Speaker Biography:
Virginia Man-Yee Lee, Ph.D., is the John H. Ware 3rd Endowed Professor in Alzheimer's Research at the University of Pennsylvania Perelman School of Medicine and Director of the Center for Neurodegenerative Disease Research. Lee’s research focuses on disease proteins that form pathological inclusions in hereditary and sporadic Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and related neurodegenerative disorders of aging. Her work demonstrated that tau, alpha-synuclein and TDP-43 proteins form unique brain aggregates in neurodegenerative diseases and provided critical evidence that aggregation of brain proteins is a common mechanistic theme in diverse neurodegenerative diseases including AD, PD, FTLD, ALS and related disorders. Significantly, Lee’s studies implicated the abnormal aggregation of tau, alpha-synuclein and TDP-43 in mechanisms that compromise neuronal viability. Most importantly, this research has opened up new avenues of research to identify targets for drug discovery to develop better treatments for these disorders.
www.med.upenn.edu/apps/faculty/index.php/g275/p125…

Producers: Kevin McLean, Lee Rossoff
Cinematographer/Sound: Kevin Flanigan, Syd Redmond
Editor: Lee Rossoff
Graphics: Chris George, Maggie Hubbard
Associate Producer: Shelley Elizabeth Carter
Executive Producers: Shannon Behrman, Sarah Goodwin, Elliot Kirschner

Except where otherwise noted, this work is licensed under
creativecommons.org/licenses/by-nc-nd/4.0/
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