Aminoglycosides | Mechanism Of Action and Side Effects🩺

Dr. Najeeb Lectures
Dr. Najeeb Lectures
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Published 2024-01-07
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Aminoglycosides | Mechanism Of Action and Side Effects🩺

This lecture is a clip from the Clindamycin Part 1 - Role of Ribosomes
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A ribosome is an intercellular structure made of both RNA and protein, and it is the site of protein synthesis in the cell. The ribosome reads the messenger RNA (mRNA) sequence and translates that genetic code into a specified string of amino acids, which grow into long chains that fold to form proteins.

Aminoglycosides are potent bactericidal antibiotics that act by creating fissures in the outer membrane of the bacterial cell. They are particularly active against aerobic, gram-negative bacteria and act synergistically against certain gram-positive organisms. Gentamicin is the most commonly used aminoglycoside, but amikacin may be particularly effective against resistant organisms. Aminoglycosides are used in the treatment of severe infections of the abdomen and urinary tract, as well as bacteremia and endocarditis. They are also used for prophylaxis, especially against endocarditis. Resistance is rare but increasing in frequency. Avoiding prolonged use, volume depletion and concomitant administration of other potentially nephrotoxic agents decreases the risk of toxicity. Single daily dosing of aminoglycosides is possible because of their rapid concentration-dependent killing and post-antibiotic effect and has the potential for decreased toxicity. Single daily dosing of aminoglycosides appears to be safe, efficacious and cost effective. In certain clinical situations, such as patients with endocarditis or pediatric patients, traditional multiple dosing is still usually recommended.
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All Comments (13)
  • @syedwaqasshah5744
    Thank you @Dr.Najeeb I Found the best lecture about Aminoglycoside on the entire internet.
  • @AbdulRehman-sg6hr
    I am truly appreciative of the comprehensive medical lecture. The information shared was incredibly valuable, and I feel better equipped to address the challenges in my field.
  • @drmusharrafshaheen
    Dr. Najeeb, your hard work in your lectures is truly appreciated. Love from the core of my heart! ❤❤❤❤ Your dedication has made complex concepts accessible, and may Allah bless you abundantly for positively impacting countless learners with your tireless efforts. Your commitment to medical education is truly inspiring.
  • @WeirdoAquarius
    @Dr. Najeeb, your comprehensive explanation of antibiotics in this video is truly outstanding! Your dedication to clarity and depth in teaching has made a significant impact on my understanding of these crucial medical concepts. The way you break down complex topics into digestible information is unparalleled. I appreciate your commitment to educate and empower students like me. Grateful for your invaluable contribution to the field of medical education. Thank you, Dr. Najeeb, for making learning an enriching experience!
  • @dr.faizanmajeed4460
    Thank you sir. Now there will be no more confusions in understanding difficult concepts of antibiotics. Please continue these clinical videos
  • @iqramir4068
    Exceptional teaching way .....masha Allah.