Hematology | Types of Anemias

:_NinjaLOVE::_NinjaHELLO::_NinjaGG::_NinjaKITTY: -- These customizable emojis can be yours to use for any of our videos! All you have to do is JOIN! youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join

Your videos saved me, I'm a visual learner and I understood everything so well instead of trying to read my confusing textbooks with long chapters. Thank you, you deserve a million views!

WOW dude!! I am not even a med student, or even remotely related to the med field in any way, but came here for Thalassemia (was diagnosed today). I am completely blown away by the quality of you, and feel so fortunate to have found your channel! Thank you SO much. You are EXCELLENT.

For those who would like a quick reference (thalassemia always trips me up): 00:55 - IDA 06:08 - B12/Folic Acid 10:38 ‐ Hereditary Spherocytosis 13:32 - G6PD 19:28 - Sickle Cell 25:05 - Hemorrhage 26:27 - Aplastic 30:18 - Thalassemia

Found you by accident and i am so grateful. I have had anemia since i was 6 or 7 (i am 53 now). I have stage 4 cirrhosis(sober 6 yrs now), chronic pancreatitis, Crohns w complications(severe anemia), UC, stage 4 COPD. In the last 3 yrs i have been on Hospice 2 times. I learned more about my anemia in 30 mins then i have my entire life.Although i am terminal, i always want to know because each day i wake up is a blessing to me. Maybe something is learn from you can give me another beautiful on this Earth. 🙂 Thank you for explaining this visually. New Sub now and looking forward to learning more from you.

You have the best videos, best explanation and best pictures! Dude's saving more lives than superman

You're a real teacher. This is awesome. I have never studied anything related but i understand what my sickness is. Thank you

I hope from the deep of my heart that you never stop doing this videos, please keep teaching cause it goes with you so much, you're born to be a medicine teacher ❤ that's helped millions

This is the most helpful video I have ever seen on the subject! You present the details and complex metabolic pathways while streamlining it all into an easy to understand simple focus. You are a gifted teacher sir! Love it! Please keep these videos coming!!!

I have a hematology exam tomorrow worth 25% of my final grade, thank you for rescuing me

Very interesting lectures in this channel. Congratulations. I think there is a couple little remarks to add: 1) Vitamin B12 comes from bacterial fermentation in the gut, and it later accumulates in animal tissues. Unlike folic acid, vitamin B12 compounds are not generally present in plant foods, with the exception of fortified breakfast cereals. Similar compounds can be found in some algae/seaweeds, but these do not have the same nutritional value of that of animal vitamin B12 sources. Because of this reason, vegans are often prescribed vitamin B12, because they also remove other essential dietary sources of cobalamins, such as eggs, and milk and diaries. 2) It might be interesting mentioning about the existance of some dietary factors that can precipitate haemolytic anaemia in those patients who have a deficiency of G6PDH (genetic condition that is more common in the Mediterranean and the Middle East countries). These compounds, called glucosides, are found in some legumes such as some varieties of beans, peas, i.e. broad beans (fava beans), and if consumed by those people who have a genetic deficiency of G6PDH, they can trigger haemolytic anaemia (in this case know as favism). Kind Regards.

Awesome video man. Keep up the good work! Here are a few extra key points in each of the Anemias you listed: 1) Iron Deficiency Anemia Extra possible causes: Can also be due to : parasitic infection, increased iron demand, malabsorpion. Extra clinical signs from the ones you mentioned are Oral lesions, Angular Cheilitis, Plummer-Vinson syndrome( Glossits, esophageal webbing,dysphagia), koilonychia, pica(desire to eat non-edible things such as clay-paint.) Upon microscopic examination we can see microcytic, hypochromic anemia with anisocytosis and poikilocytosis with presence of target cells. 2.1)B12Folate Deficiency: Peripheral Blood smear= Presence of Hyoersegmented neutrophils, target cells, polychromasia, Howell-Jolly bodies. Measure methylmalonic acid should be elavated. Presents with neurological symptoms 2.2)Foliate deficiency : Occurs due to increased demand during pregnancy, due to alcoholism, due to anti-folate drugs( Methotrexate), or due to malabsorption Measure homosysteine levels( should be elevated). No neurological symptoms are present. 3)Hereditary spherocytosis= Intracorposcular origin. Patients also appear with jaundice. Perform splenectomy to correct reduce anemia. 4)G6PD deficiency= Intracorposcular origin Clinical Signs : Back pain, Hemoglobinemia, Hemoglobinuria 5)Sickle cell Anemia( Intracorposcular- Extravascular) Extra clinical signs= Pain, micro-infarcts, necrosis in joints, bones , GI, lungs, aplastic crisis, sequestration crisis. Extra Treatment= Bone marrow transplant 6)Aplastic Anemia Normocytic, normochromic pancytopenia. Signs and symptoms= Palor,weakness, Petechiae haemorrhages, ecchymosis, mucosal bleeds, recurrent infections, thrombocytopenia, Granulocytosis. Treatment: Antithymocyte Globulin, corticosteroids, Cyclosporine, Cytokines administration( EPO, G-CSF, GM-CSF) , Bone marrow transplant.

This IS THE BEST explanation of basic hematology I have ever had!! Thank you for your talented presentation style as well as your solid understanding of this complicated topic.

I wish everything in life was this clearly explained.

Thank you so much, my daughter relying on you on her first year of med school. Being a first year med student in pandemic era that turned every class into online is a tough experience and you helped her soo much. She even thank God for making you exist in this world😊 Sending lots of love from Indonesia💓

Just in case anyone is watching this, MCV is typically in the range of 80-100. Depends on what lab reports you're looking at and what region you're in, but typically macrocytic is above 100 and microcytic is below 80. Always check what your school lists as normocytic though. Thank you so much for your videos, you've saved me in medical school multiple times.

This was the best and most informative video I’ve ever seen. I’ve struggled with Anemia for half my life. You’ve made it so much easier to understand. Thank you.

Literally blow up my mind . Sir I am in med school and I thought that I'll Be doomed in physiology but You are a life saver and I mean Your enthusiasm while teaching is really addictive. Please keep on making these videos.❤

Hands down one of the best explanations I have heard yet! Thank YOU! I Needed this.

Great dude! But remember hereditary spherocytosis is diagnosed by a test called osmotic fragility instead of Coombs, this thing is used to differentiate Autoimmune from non autoimmune hemolytic anemia. Treatment might be different because I would use corticosteroids to block antibodies against RBC in an autoimmunity setting.