This is your brain on ketamine

I've never heard anyone ever call it "super acid."

Ketamine, lsd, dmt and psilocybin containing mushroom are amazing. I was severely traumatized years ago as a teenage, got diagnosed with ADHD. Spent my whole life fighting ADHD. I suffered severe depression and mental disorder. Not until my husband recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 8 years totally clean. Never thought I would be saying this about mushrooms.

the “you can’t have any fun” thing is real, i had a ketamine doctor refuse to treat me — despite the fact ive already had ketamine infusions and it improved my depression— because i admitted to drinking alcohol and using cannabis. he literally said the chances are too high that i would enjoy the treatment and thus seek more. you’re right dude, i enjoy being less depressed and am thus seeking more ketamine. why is it bad if it’s not unpleasant to be helped!? (all the ketamine under discussion has been administered in person by an md)

I work in rheumatology and see a lot of chronic pain patients get amazing relief with k infusions. Meeting patients, it’s clear how life saving this is. Quality of life is so much better for them now ❤

Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.

As someone with treatment resistant CPTSD, this is super exciting news. I've suffered for years with my symptoms - and we lost my older brother in 2023 to his. I've been trying to get into an MDMA study for years. Hearing that it's slated for review in barely over a month makes me want to cry happy tears.

It's so refreshing to hear someone from your class who believe in bodily autonomy. I believe people should be able to whatever they want with their body. It's so weird that people can't. Like people are children or something.

Trying to extract only the part of ketamine that helps with depression while trying to remove the psychedelic aspects of it doesn't quite hit for me. I feel like the psychedelic aspects is what helps with the depression

GOD FORBID someone who doesn't experience happiness....experiences fleeting happiness! We can't have that in America, the people might wake up and be harder to control!

I did get Ketamine right before my hip joint replacement procedure, at least I stopped screaming with pain. It felt like I was in a discotheque in the late 1970s. Flashing pink lights like stroboscopes. A very weird experience. When they wheeled me into the operting theatre, I was out. The procedure went very well and I couldn't remember anything. In the case of knocking out a patient before a surgical procedure, nice way to go with Ketamine. I wouldn't want to use it in any other way.

Ketamine infusion therapy greatly helped me in recovering from cPTSD but you have to do the work yourself to truly heal!

I have been doing at home ketamine therapy via telemedicine for anxiety and depression. It seemed to work wonders at first. I felt energized and unburdened. Though I was progressively increasing the dosage I felt like I was getting less benefit as time progressed. It never caused any problems I could detect either so it has not been a negative. If nothing else I completely lost my urge to drink. I was not drinking a lot but I am a health and fitness nut and drinking alcohol never sat right with me. I am grateful that ketamine helped me quit without feeling like I am missing out on anything. I have a couple doses left but I have been going a long time between doses and I don't plan to continue ketamine therapy. I feel like my anxiety and depression are very situational and that is probably why I can't seem to shake them. Maybe if my life circumstances change I will get relief.

“prisoner volunteers” lol my ass

Did 0,5g ketamine + 250ug lsd last year in february. I was completely washed of egoic stains that had covered my psyche. Changed my whole life up and I felt stable for about 8 months, never remember being so mentally healthy for that amount of time. Then life situations sent me into a generalized anxiety disorder, did ketamine + lsd again about 1 year after the first time and it helped. It wasn't like the first experience but I definitively had a good time and worked through some mental stuff :) Edit: ‼This is not a small dose and should definitely not be concidered if you aren't very familiar with psychedelics/dissociatives! xD‼

I have taken a small amount of Ketamin every weekend for about 3 years. In small amounts it can give you unmatched gratitude, perspective and empathy for others. It can show you what you need to see within yourself and in the world around you

8:30 it's not so much about glutamate system dysfunction, but rather that glutamate signalling influences BDNF release. Blockage of NMDA ligand gated ion channels via Ketamine leads to rapid BDNF realease. This is turn promotes the formation of new synaptic connections (neuroplasticity and ability to adapt/learn/change thought patterns) and has anti-inflammatory and anti-apoptotic effects. Other things proven to improve depression, such as TCAs, SSRI and SNRI also lead to increased BDNF levels (with TCAs being the most potent), as do psychotherapy, doing sports, environmental enrichment and serotoninergic psychedelics (i.e. psilocybin, LSD - interestingly enough they also bind to 5-HT2A-mGlur2 and 5-HT2A-D2 receptor heteromers. many other receptors can fuse with one another aswell. This opens up a whole new field of study and implicates a vast amount of yet unknown interactions and mechanisms). Anyhow, BDNF is where most of the different depression models converge, since marks the point of intersection between them.

I always find it interesting that they want two other types of antidepressants to fail first before trying the one that works when those ones don't. Those ones can lead to suicidal thoughts, Spravato can relieve suicidal thoughts. Hmmm... Let's try the one that causes suicidal thoughts first... twice. I know someone who was heavily depressed about 11 years ago. Zoloft had done nothing in the past, cymbalta gave them daytime hallucinations, and then Wellbutrin almost led to them ending their life. I didn't find out that they we're having suicidal thoughts until a year later. Maybe start with the safer one first (I know it's not without risk) and if that one doesn't work, then try the one that can cause suicidal thoughts.

And as it was mentioned just the wealthy have access to the treatments. But the thing is that the non wealthy people are the most affected by depression and major depression episodes leaving the society sick.

Psychedelics are just an amazing discovery. It's quite fascinating how effective they are for depression and stress..saved my life.

I was in a band called Cicada In My Pants years ago, but now it’s dormant.